In adult sickle anemia patients, does the use of morphine in addition to NSAIDS decrease chronic pain compared to NSAIDS alone?

PICOT Question

In adult sickle anemia patients, does the use of morphine in addition to NSAIDS decrease chronic pain compared to NSAIDS alone?
Population: Adult sickle cell Anemia patients (<50yrs)
Intervention: The use of morphine in addition to NSAIDS during Chronic pain
Comparison: The use of only NSAIDS
Outcome: Understand if the addition of morphine decreases chronic pain during sickle cell crisis.
Time: One year

References
Geller, & O’Connor. (2008). The sickle cell crisis: a dilemma in pain relief. Mayo Clinic Proc , 83:320-323.
Rees, Williams, & Gladwin. (2010). Sickle-cell disease. . Lancet , 376(9757); 2018-2031

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